CB 399: Extracellular Vesicles in Human Pathologies

Extracellular Vesicles in Human Pathologies

For more than two decades since extracellular vesicles were first discovered, they were considered to be the waste products of cells and therefore, of little biological significance. Only recently have scientists discovered that extracellular vesicles contain proteins and genetic material and can have potential physiologic and pathologic roles. During the past decade, extracellular vesicles have emerged as novel mediators of a variety of human pathologies and have become a rapidly growing area of biomedical research.
This course provides an overview of the foundational knowledge in the area of extracellular vesicles, current misconceptions with respect to them, and challenges in this research field. The first session is comprised of interactive lectures covering the biology of extracellular vesicles and their role in different human pathologies including cancer, neurodegenerative, and cardiovascular diseases. In the second session, we will discuss the translational potential of extracellular vesicles as diagnostics and therapeutics and the current advances in this field.

Class Assignments
Registered students will be asked to fill a survey prior to the first session which evaluates their current knowledge of the extracellular vesicles and their purpose for taking the course.
For the final session, students will submit a potential research question about extracellular vesicles in their field of interest and a one-page research proposal to address this question, due 3 days before the session. The submitted proposals will be distributed to all students. The third session will include 5-min presentations of the proposal, followed by class discussions.

Course Instructors: Golnaz Morad (golnaz.morad@childrens.harvard.edu); Gareth Willis (gareth.willis@childrens.harvard.edu) and Christine Coticchia (ccoticchia@exosomedx.com)
Course Director: Marsha A. Moses (marsha.moses@childrens.harvard.edu)
Curriculum Fellow: Ryan Lee (ryan_lee@hms.harvard.edu)

Session Dates and Times
First Session Date: Wednesday, May 15 2019; 10:00am - 12:00pm
Location: TMEC 209
Second Session Date: Thursday, May 16 2019; 10:00am - 12:00pm
Location: Cannon Room
Third Session Date: Wednesday, May 22 2019; 2:00 - 4:00pm
Location: TMEC 151 (for registered participants only)