CB 399: HEART MUSCLE REGENERATION Fall 2013

HEART MUSCLE REGENERATION
Nanocourse Director(s): Caroline Burns, Ph.D.; Ibrahim Domian, M.D., Ph.D.; Bernhard Kuhn, M.D.
; Geoffery Burns, Ph.D.
Curriculum Fellow: Abha Ahuja, Abha_Ahuja@hms.harvard.edu

Heart disease, one of the most important public health problems worldwide, is directly related to the inadequate regenerative activity in human hearts. This course will provide a broad overview of important advances that were made in the cardiac regeneration field by using different approaches and model organisms. We will begin by discussing the significance of heart disease and the challenges of developing regenerative therapies. We will present advances into understanding the molecular and cellular mechanisms of myocardial regeneration using a regenerating model organism (zebrafish) as well as poorly regenerating model organisms (mouse, rat, humans). Finally, we will present an overview of translational and clinical research efforts using cell transplantation as an approach to boost the regenerative activity in mammalian hearts.

Schedule:

First Session: Wednesday, November 6, 2013 1 - 4 PM
Location: TMEC Building, Walter Amphitheater
 
Second Session: Wednesday, November 13, 2013 1 - 4 PM
Location: TMEC Building, Room 448

SUGGESTED PRIOR READING:

Laflamme MA, Murry CE. Heart regeneration. Nature 2011;473:326-35

Garbern JC, Lee RT. Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell 2013; 12(6):689-98

Xin, M, Olson, EN, Bassel-Duby, R. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nature reviews. Molecular cell biology 2013; 14(8):529-41

 

ASSIGNMENT (for registered students only):

Students enrolled in this nanocourse will each review and present one paper. Registered students can view papers by logging in. These presentations will be given to the group of registered students and course faculty on day 2.

Registered students please login to download course documents (at the bottom of the page).

 

DROP DEADLINE: Wednesday, October 30, 2013

AUDITORS (Post-Docs, Faculty, or Staff) DO NOT NEED TO SIGN UP TO ATTEND THE 1st SESSION.  PLEASE DO NOT ENROLL