CB 399: Epigenetics and the Rise of Allelic Non-Equivalence Fall 2009

Intellectual Unit:

Epigenetics and the Rise of Allelic Non-Equivalence

Course Lecturers: Andrew Chess and Jeannie Lee

Curriculum Fellow: Dr. Sarah Wojiski

While it is generally assumed that when a given gene is turned on, its transcripts come from both alleles. However, there are a number of interesting exceptions that will be the focus of this course. We will explore aspects of X-inactivation, imprinting (parent-of-origin determined) and random monoallelic expression on autosomes. In thinking about epigenetics, monoallelic expression is inherently interesting because within the same nucleus, two sequence-equivalent (indeed sometimes sequence-identical) pieces of DNA are somehow differentially regulated even though they are exposed to the same transcription factor milieu.

First Meeting: Monday, December 7th, 1-4:30pm

Location: TMEC Bldg., Room 227

Second Meeting: Friday, December 11th, 12:30-3:00pm

Location: TMEC Bldg., Room 333

Recommended Readings

Instructions and Course Documents