CB 399: Immune System Molecules in Three Dimensions Fall 2012

Intellectual Unit:

Immune System Molecules in Three Dimensions
Nanocourse Faculty: Hao Wu and Timothy Springer
Curriculum Fellow: Zofia Gajdos (zofia_gajdos@hms.harvard.edu)

 In the first meeting, students will learn PyMol, a freely downloadable molecular visualization tool, and basic aspects of structural biology through exploration of the structures of molecules of the immune system. We will discuss the atomic interactions that hold three dimensional structures together, the units of secondary structure,  tertiary folds including all alpha, beta, and alpha+beta, and the atomic interactions/forces that drive quaternary changes including receptor-ligand binding and allostery.   We will discuss domains and quaternary structures in the extracellular, membrane, and cytoplasmic domain environments. In the second meeting, each student will present a live PyMol demonstration of a single domain, molecule or receptor/ligand pair in the immune system. In the presentation, the student will integrate functional and mutational data from the literature with three dimensional inspection of the structure to illustrate the structural basis of function.

 All attendees are required to download the free Pymol software to a laptop before the first session of the course. Go to http://pymol.org/edu/, and register yourself. Then you will receive a user name and password for downloading the program. Please also go to http://ihome.cuhk.edu.hk/~b102142/pymol/pymol_tutorial.html for a brief tutorial and feel free to explore the program on your own - and please remember to bring your laptop to the course.

Schedule:

First Session: Friday, November 9, 2012 1-4 PM
Location: Modell Immunology Center, Fred S. Rosen Lecture Hall 100A
 
Second Session:Friday, November 30, 2012 1-4 PM
Location: Modell Immunology Center, Fred S. Rosen Lecture Hall 100A

 

DROP DEADLINE: Friday, November 2, 2012 

 

AUDITORS (Post-Docs, Faculty, or Staff) DO NOT NEED TO SIGN UP TO ATTEND THE 1st SESSION.  PLEASE DO NOT ENROLL.