CB 399: Chromatin Modifications and Epigenetic Regulation of Gene Expression Fall 2009

Intellectual Unit

Chromatin Modifications and Epigenetic Regulation of Gene Expression

Course Lecturers: Robert Kingston (HMS), Danesh Moazed (HMS), and Bradley Bernstein (HMS)

Curriculum Fellow: Dr. Sarah Wojiski

Although each cell within an organism possesses the same DNA, the variability in gene expression between cells is critical in defining cell type and function. Much of the regulation of gene expression is defined by alterations in chromatin state that heritably determine if a gene is expressed or not. An open or active chromatin state is often associated with gene expression, while a closed or inactive chromatin state is often associated with gene silencing. This nanocourse will discuss the various modifications that can be made to chromatin, such as the remodeling of nucleosome position, covalent modification of nucleosomes, the generation of heterochromatin, the role of small RNAs in targeting chromatin modifications, and the numerous protein complexes that carry out these functions. The role of genome-wide chromatin states during development and disease will also be discussed.

First Meeting: Tuesday, November 10th, 1-4:30pm

Location: Armenise Amphitheater

Second Meeting: Friday, November 13th , 2-4:30pm

Location: TMEC Bldg., Room 333

Recommended Readings

Instructions and Course Documents