CB 399: Chromatin Dynamics: A Molecular Approach Fall 2010

Intellectual Unit:

Chromatin Dynamics: A Molecular Approach
Nanocourse Director: Fred Winston     
Curriculum Fellow: Leah S. Brault lbrault@genetics.med.harvard.edu
Lecturers: Raul Mostoslavsky, Danesh Moazed and Johnathan Whetstine

The genetic information encoded in our DNA is organized in a defined set of chromosomes, which are condensed about 10.000 fold in order to fit in the cell nucleus. This compaction occurs through packaging of the DNA around histone proteins, a structure known as chromatin. In what was thought to be a rigid structure, today we know that chromatin is an amazingly dynamic folding that plays a crucial role in controlling accessibility of factors to the DNA, and as such, it regulates a vast number of critical biological functions, including gene transcription, DNA replication, DNA repair and cellular identity. In this course we will attempt to cover some of the basic molecular mechanisms that play a role in regulating chromatin dynamics. We will discuss the role of DNA methylation, histone modifications and nucleosome dynamics in the context of different biological processes for which chromatin accessibility plays a crucial role.

  

Schedule: 

First Session: Tuesday, November 9, 1:00 pm – 4:30 pm
Location: TMEC, Walter Amphitheater
 
Second Session: Monday,
November 15, 2:00 pm – 4:30 pm
Location: Countway Library, Ballard Room

 

Drop Deadline: Tuesday, November 2, 2010

 

Assignment:

You will find a number of papers posted to this website, and a Word document listing questions for each one.  Never fear...you don't have to read all of them!  Everyone should read McKnight and Miller, and Prior et al.  Everyone should also prepare an answer for the first question on the Word document.  You will then find below that you have each been assigned to a group.  Each group must read a subset of the posted papers, and prepare answers to the questions pertaining to those papers.  Paper assignments are as follows:

Group 1: Rechtsteiner et al., Hansen et al.

Group 2: Peng et al., Lee and Mahadevan

Group 3: Kim et al., Tahiliani et al., Loenarz and Schofield

Please see below for your group assignment.  If you have any questions, please do not hesitate to contact the curriculum fellow.

Group 1:  D. Drake, A. Lord, S. Conwell, C. Lu, K. Martinod

Group 2:  J. Akin, Adriana, M. Sheng Lau, K. Hwang, I. Netravali

Group 3:  B. Morris, Y. Qi, C. Sindhu, H. Kuhn, B. Beliveau

  

 

AUDITORS (Post-Docs, Faculty, or Staff) DO NOT NEED TO SIGN UP TO ATTEND THE 1st SESSION.  PLEASE DO NOT ENROLL.