CB 399: Phagocytes: More than just Bacterial Killing

Intellectual Unit:

Phagocytes: More than just Bacterial Killing


Nanocourse Director: Hongbo R. Luo and Wolfgang Junger
Curriculum Fellow: Narveen Jandu

Course Description: Professional phagocytes, including neutrophils and macrophages protect the host by clearing invading microorganisms.  Phagocyte accumulation at inflammatory sites is an important component of this innate immune response.  However, excessive phagocyte recruitment and activation can damage surrounding host tissues and cause unwanted inflammation and host organ injury.  In addition, growing evidence suggests that phagocytes participate in many other physiological and pathological processes (e.g.  hematopoiesis and tumor microenvironments).  In this nanocourse, we will explore the roles of phagocytes in such processes and the consequences of dysfunctional phagocyte regulation.  Topics covered include biology of phagocytes, phagocyte trafficking, clearance of neutrophils by macrophages, acute lung injury, multiple organ failure, chronic inflammation (e.g. rheumatoid arthritis), the role of phagocytes in tumorigenesis and hematopoiesis, and therapeutic strategies to control phagocyte function. Emphasis will be placed on the mechanisms of how phagocytes and their products affect the function and fate of the target cells.  


First Session: Tuesday, November 16, 1:30 – 4:30 pm
Location: TMEC Building, Room 209
 
Second Session: Tuesday, November 23, 1:30 – 4:30 pm

Location: TMEC Building, Room 333


Assignment: For all registered students taking this course for credit, please decide which of the following topics you would like to research: (1) regulation of hematopoiesis; (2) transfusion-related acute lung injury (TRALI); (3) reperfusion-related lung injury; (4) tumor microenvironment; (5) neuron degeneration; (6) antigen presentation; or (7) any other processes related to normal or dysregulated phagocyte function (please check with course directors).  Each registered student will prepare a short write-up (250-300 words) on one of the research topics.  During Day 2 of this nanocourse, each student will then share and discuss the topic that they researched with the rest of the group.  On Day 2 of this nanocourse, you will also have the opportunity to ask the lecturer in-depth questions related to your research topic. This assignment must be submitted for credit.

 

See below for COURSE READINGS


 Drop Deadline: Tuesday, November 9, 2010

 

AUDITORS (Post-Docs, Faculty, or Staff) DO NOT NEED TO SIGN UP TO ATTEND THE 1st SESSION.  PLEASE DO NOT ENROLL.