CB 399: The Machinery of the Ubiquitin System Fall 2010

Intellectual Unit:

The Machinery of the Ubiquitin System
Nanocourse Director: Daniel Finley, Wade Harper, Randy King
Curriculum Fellow: Ondra Kielbasa

The ubiquitin-proteasome pathway (UPP) is widely used to control flux through signaling pathways. This constitutes one the most complex regulatory systems in nature–virtually every aspect of eukaryotic cell biology is linked in one way or another to the UPP. In addition to ubiquitin itself, several additional ubiquitin-like proteins are also known to be conjugated to other proteins to regulate their activities. This nanocourse will explore the machinery of the ubiquitin conjugation system as well as the central mechanistic themes that underlie control of important cellular pathways. Moreover, the regulation of protein turnover by the proteasome and autophagy pathways will addressed. Emphasis will be placed on functional modules within the ubiquitin system, regulatory pathways, and how ubiquitin networks are linked to phosphorylation and other signaling networks. 

First Session: Wednesday, November 3, 1-4:30
Location: Goldenson 122
 
Second Session: Wednesday, November 10, 1-3:30
Location: TMEC Bldg., Room 447

 

PLEASE SCROLL DOWN FOR PDF FILES (READINGS AND LECTURES)


DROP DEADLINE: Wednesday, October 27, 2010

 

AUDITORS (Post-Docs, Faculty, or Staff) DO NOT NEED TO SIGN UP TO ATTEND THE 1st SESSION.  PLEASE DO NOT ENROLL.