CB 399 Regeneration in the Nervous System: comparing CNS versus PNS Spring 2010

Regeneration in the Nervous System: comparing CNS versus PNS.
Course Lecturers: Clifford Woolf PhD, Larry Benowitz PhD,  Zhigang He PhD, BM
Course Organizer: Catherine Dubreuil PhD, Catherine_Dubreuil@hms.harvard.edu
Curriculum Fellow: Johanna Gutlerner, Johanna_Gutlerner@hms.harvard.edu

Injury to both the central and peripheral nervous systems can cause major cell death, inflammation and neuronal degeneration, which frequently results in devastating and permanent effects such as sensory loss or paralysis. Both types of lesions are extremely complex and involve multiple cell types, including neurons and glia. In recent years much attention has been focused on promoting regeneration of injured nerve cells by understanding the underlying mechanisms of growth inhibition and survival with the ultimate hope of functional recovery. However, despite the progress that has been made in this area over the last several years, few effective clinical therapies are available to date. In addition, underlying signaling pathways and feedback loops regulating neuronal growth and cellular repair in such lesions are highly complex and interconnected. Thus, promoting regeneration and repair is extremely difficult and combinatory synergistic approaches may be a useful treatment strategy. This course will explore the mechanisms involved in promoting repair and regeneration in an injured nervous system and will also highlight recent promising therapeutic avenues.

First Meeting: April 22nd 12:30 – 4:00 pm
Location: TMEC Bldg., Room 227

Second Meeting: April 26th 1 – 3:30 pm
Location: TMEC Bldg., Room 447


Student session:

Students enrolled in the course will be asked to discuss one of the following questions (the main focus of the discussion will be on the use of cell replacement therapies in the CNS following injury):

1. discuss the use of stem cells as therapy after central nervous injury. Highlight the pros and cons as well as the use of stem cells following PNS and CNS injury.

2. discuss the use of combination therapies following central nervous system injury: are they the same for PNS and CNS and why.

Students can also refer to: Experimental Neurology 223 (2010), this issue focuses on regeneration in the nervous system

Please Enroll/Un-enroll for this nanocourse below: